The North Carolina quarter, the 12th in the series and the second quarter released in 2001, highlights the famous 1903 photograph of the "First Flight."

The North Carolina quarter commemorates the historic feat that took place on December 17, 1903, at Kitty Hawk, North Carolina with the first successful flight of a heavier-than-air, self-propelled flying machine. The craft, called the Flyer, traveled a distance of approximately 37 meters (120 feet) on its first flight and soared even further as one of the most significant human achievements in history.

Governor James B. Hunt appointed the North Carolina Department of Cultural Resources as the lead in the state's design concept process. The Department established the North Carolina Commemorative Coin Committee, which consisted of members from the State Department of Cultural Resources, the Division of Archives and History, as well as coin collectors. The Committee solicited design ideas from the residents of North Carolina.

Some alternate design concepts suggested were the 1903 Flyer superimposed over an outline of the state, the Hatteras Lighthouse superimposed over an outline of the state, and the Hatteras Lighthouse showing a dune and sea gulls. On June 5, 2000, the Governor was provided with three candidate designs, and the Committee and Governor Hunt selected the "First Flight" theme for the official design.